*Hmmm. This is the most alarmist article about space medicine that I've ever read.
https://slim-weight.info/story/how-space-tries-kill-you-make-you-ugly/%3C/p%3E%3Cdiv%3E%3C/div%3E%3Cdiv%3E%3C/div%3E%3Cp class="paywall">Oddly most space-veteran astronauts I've met looked really perky
(...)
Here are the 34 known risks of space travel—risks that go beyond basic mechanical dangers, such as the rocket blowing up.
concern about clinically relevant unpredicted effects of medication
concern about intervertebral disc damage upon and immediately after reexposure to gravity
risk of acute (in-flight) and late central nervous system effects from radiation exposure
risk of acute radiation syndromes due to solar particle events
risk of adverse cognitive or behavioral conditions and psychiatric disorders
risk of adverse health and performance effects from celestial dust exposure
risk of adverse health effects due to host-microorganism interactions
risk of adverse health events due to altered immune response
risk of adverse health outcomes and decrements in performance due to in-flight medical conditions
risk of an incompatible vehicle / habitat design
risk of bone fracture due to spaceflight-induced changes to bone
risk of cardiac rhythm problems
risk of cardiovascular disease and other degenerative tissue effects from radiation exposure and secondary spaceflight stressors
risk of decompression sickness
risk of early-onset osteoporosis due to spaceflight
risk of impaired control of spacecraft / associated systems and decreased mobility due to vestibular / sensorimotor alterations associated with spaceflight
risk of impaired performance due to reduced muscle mass, strength, and endurance. (((etc etc etc)))